In-vivo evaluation of hepatic function using dynamic Gd-EOB-DTPA enhanced MRI with a dual-input one output two-compartment pharmacokinetics model

نویسندگان

  • Jia Ning
  • Sheng Xie
  • Lei Wang
  • Hua Guo
  • Xihai Zhao
  • Chun Yuan
  • Huijun Chen
چکیده

vein d) tissue; and e) the concentration profiles and fitted result. Fig.1: Schematic diagram of perfusion model, orange dots are Gd-EOB-DTPA In-vivo evaluation of hepatic function using dynamic Gd-EOB-DTPA enhanced MRI with a dual-input one output two-compartment pharmacokinetics model Jia Ning, Sheng Xie, Lei Wang, Hua Guo, Xihai Zhao, Chun Yuan, and Huijun Chen Center for Biomedical Imaging Research & Department of Biomedical Engineering, Tsinghua University, Beijing, China, Department of Radiology, China-Japan Friendship Hospital, Beijing, China, Department of radiology, University of Washington, Seattle, WA, United States

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dynamic-contrast-enhanced magnetic resonance imaging of cirrhotic liver parenchyma: A comparison between gadolinium-diethylenetriamine pentaacetic acid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid.

BACKGROUND The newly developed magnetic-resonance-imaging (MRI) hepatocyte-specific contrast agent, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has different excretion pathways from the conventional MRI contrast agent, gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). In this study, we compare the enhancement effect of the liver and renal parenchyma betwee...

متن کامل

Gd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry

Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagn...

متن کامل

Added value of Gd-EOB-DTPA-enhanced Hepatobiliary phase MR imaging in evaluation of focal solid hepatic lesions

BACKGROUND Correct characterization of focal solid hepatic lesions has always been a challenge and is of great diagnostic and therapeutic relevance. The purpose of this study was to determine the added value of hepatobiliary phase images in Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for differentiating focal solid hepatic lesions. METHODS In this retrospective trial 84 consecutive ...

متن کامل

Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI

Published articles have been reprinted with the permission of the copyright holder. Abstract ABSTRACT The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients. Ten healthy volunteers were examined with both co...

متن کامل

Peripheral low intensity sign in hepatic hemangioma: diagnostic pitfall in hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI of the liver.

PURPOSE To describe the presence of "peripheral low intensity sign" in hepatic hemangioma in the hepatobiliary phase (HP) of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and to compare the frequency of this sign between hepatic hemangiomas and hepatic metastases. MATERIALS AND METHODS The Institutional Review Board approve...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013